| Название | Жанр | Статус |
| S.T.A.L.K.E.R.: Shadow of Chernobyl | 1stPerson / 3D / Action / Shooter |  |
| Sacred | Action / Isometric |  |
| Sacred Underworld | Action / Add-on / RPG / Isometric | |
| Saga of Ryzom (The) | 3D / 3rdPerson / MMORPG | |
| Savage: The Battle for Newerth | 3D / 3rdPerson / Action / MMOG / RTS / Strategy | |
| Scrapland | 3D / 3rdPerson / Action / Arcade / Racing | |
| Second Sight | 3D / 3rdPerson / Action / Shooter / Stealth | |
| Secret of the Silver Earring (The) | 3D / Adventure / Quest | |
| Serious Sam 2 | 1stPerson / 3D / Action / Shooter | |
| Serious Sam: The First Encounter | 1stPerson / 3D / Action / Shooter | |
| Serious Sam: The Second Encounter | 1stPerson / 3D / Action / Shooter | |
| Settlers: Heritage of Kings (The) | 3D / RTS / Strategy | |
| Shade: Wrath of Angels | 3D / 3rdPerson / Action / Shooter | |
| Shadow Fight | 3D / 3rdPerson / Action / Arcade | |
| Shadow Vault | Strategy / TBS / Isometric | |
| Shadowgrounds | 3D / 3rdPerson / Action | |
| Shark Tale | 3D / 3rdPerson / Arcade | |
| Shogun: Total War | 3D / RTS / Strategy / TBS / Wargame | |
| Sid Meier's Pirates! | 3D / Arcade | |
| Silent Hill 3 | 3D / 3rdPerson / Action / Horror | |
| Silent Hill 4: The Room | 3D / 3rdPerson / Action / Horror | |
| Silent Hunter 3 | 3D / Simulator | |
| SimCity 4 | 3D / God Sim / Manage / RTS / Strategy | |
| Sims 2 (The) | 3D / God Sim / Manage / RTS / Strategy | |
| Sims 2: Nightlife (The) | 3D / Add-on / God Sim / Manage / Strategy | |
| Sims 2: Open for Business (The) | 3D / Add-on / God Sim / Manage / Strategy | |
| Sims 2: University (The) | 3D / Add-on / God Sim / Manage / RTS / Strategy | |
| Singles 2: Triple Trouble | 3D / God Sim / Manage / RTS / Strategy | |
| Singles: Flirt up your Life! | 3D / God Sim / Manage / RTS / Strategy | |
| Soldiers: Heroes of World War II | 3D / RTS / Strategy | |
| Soldner: Marine Corps | Action | |
| Soldner: Secret Wars | 3D / 3rdPerson / Action / Shooter / Tactical | |
| Space Rangers | Adventure / Arcade / 2D / RPG / Strategy / TBS | |
| Space Rangers 2: Rise of the Dominators | 3D / Arcade / 2D / RPG / RTS / Strategy / TBS | |
| Special Forces: Nemesis Strike | 3D / 3rdPerson / Action / Shooter | |
| Specnaz: Project Wolf | 1stPerson / 3D / 3rdPerson / Action / Shooter / Tactical | |
| SpellForce 2: Shadow Wars | 3D / 3rdPerson / RPG / RTS / Strategy | |
| Spider-Man 2: The Game | 3D / 3rdPerson / Action | |
| Star Heritage 0: Ship of Ages | 3D / 3rdPerson / Action / RPG | |
| Star Heritage: The Black Cobra | Adventure / 2D / Quest | |
| Star Wars Galaxies: Jump to Lightspeed | 3D / 3rdPerson / Add-on / MMORPG / Simulator | |
| Star Wars: Empire at War | 3D / RTS / Strategy | |
| Star Wars: Knights of the Old Republic | 3D / 3rdPerson / RPG | |
| Star Wars: Knights of the Old Republic 2 - The Sith Lords | 3D / 3rdPerson / RPG | |
| Star Wars: Republic Commando | 1stPerson / 3D / Action / Shooter | |
| Star Wolves | Strategy | |
| StarRush | 3D / Simulator | |
| Starship Troopers | 1stPerson / 3D / Action / Shooter | |
| Still Life | Adventure / Quest | |
| Stolen | 3D / 3rdPerson / Action / Shooter / Stealth | |
| Street Racing Syndicate | 3D / Arcade / Racing | |
| Strength & Honour | 3D / RTS / Strategy / TBS | |
| Stronghold 2 | 3D / Manage / RTS / Strategy | |
| Sudden Strike: Resource War | RTS / Isometric | |
| Suffering (The) | 1stPerson / 3D / 3rdPerson / Action / Horror / Shooter | |
| Suffering: Ties That Bind (The) | 1stPerson / 3D / 3rdPerson / Action / Horror / Shooter | |
| Super Mario 3: Mario Forever | Arcade / 2D | |
| SuperPower 2 | 2D / RTS / Strategy | |
| SWAT 4 | 1stPerson / 3D / Action / Shooter / Tactical | |
| Syberia | 3D / Adventure / 2D / Quest | |
| Syberia 2 | 3D / Adventure / 2D / Quest | |
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